Vaginal Colonization by ProbioticLactobacillus crispatusCTV‐05 Is Decreased by Sexual Activity and Endogenous Lactobacilli

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Vaginal colonization by probiotic Lactobacillus crispatus CTV-05 is decreased by sexual activity and endogenous Lactobacilli.

BACKGROUND Two potencies of gelatin capsules containing Lactobacillus crispatus CTV-05 were evaluated for safety and vaginal colonization in 90 young women. METHODS Sexually active females aged 14-21 years were randomized to receive either 10(6)- or 10(8)-cfu CTV-05 capsules inserted intravaginally twice daily for 3 days. At enrollment and at 4 weekly follow-up visits, behavioral and demograp...

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Vaginal Protection by H2O2-Producing Lactobacilli

Background: Peroxide-producing lactobacilli provide protection from infection for the female reproductive tract. However, in vitro studies demonstrated that H2O2-produced by Lactobacillus is not the cause of inhibition of pathogens. It is not exactly known how H2O2producing lactobacilli are involved in the protection of the vaginal environment. Objectives: This study aimed to evaluate the impor...

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Vaginal Protection by H2O2-Producing Lactobacilli

BACKGROUND Peroxide-producing lactobacilli provide protection from infection for the female reproductive tract. However, in vitro studies demonstrated that H2O2-produced by Lactobacillus is not the cause of inhibition of pathogens. It is not exactly known how H2O2-producing lactobacilli are involved in the protection of the vaginal environment. OBJECTIVES This study aimed to evaluate the impo...

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Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli

BACKGROUND H2O2 produced by vaginal lactobacilli is believed to protect against infection, and H2O2-producing lactobacilli inactivate pathogens in vitro in protein-free salt solution. However, cervicovaginal fluid (CVF) and semen have significant H2O2-blocking activity. METHODS We measured the H2O2 concentration of CVF and the H2O2-blocking activity of CVF and semen using fluorescence and in ...

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Antimicrobial activity of vaginal lactobacilli against Gardnerella vaginalis and pathogens

Bacterial Vaginosis (BV) is a vaginal inflammatory disease, related to the high percentage of recurrences and serious obstetric, gynecological and reproductive problems. This is the reason why microbiologists and gynecologists search for new methods in the treatment and prevention of this condition. In this regard, the characterization of the biological activity of vaginal lactobacillus, that h...

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ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 2009

ISSN: 0022-1899,1537-6613

DOI: 10.1086/598686